Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid‐induced DNA damage

Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid‐induced DNA damage

Abstract Background The risk of esophageal adenocarcinoma (EAC) is associated with gastro‐esophageal reflux disease (GERD) and obesity. Lipid metabolism‐targeted therapies decrease the risk of progressing from Barrett's esophagus (BE) to EAC, but the precise lipid metabolic changes and their ro...

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Bibliographic Details
Main Authors: Jeffrey Molendijk, Cathryn M. Kolka, Henry Cairns, Sandra Brosda, Ahmed Mohamed, Alok K. Shah, Ian Brown, Mark P. Hodson, Thomas Hennessy, Guanghao Liu, Thomas Stoll, Renee S. Richards, Michael Gartside, Kalpana Patel, Nicholas J. Clemons, Wayne A. Phillips, Andrew Barbour, Johan A. Westerhuis, Michelle M. Hill
Format: Article
Language:English
Published: Wiley 2022-05-01
Series:Clinical and Translational Medicine
Subjects:
Barrett's esophagus
esophageal adenocarcinoma
FADS2
lipid desaturation
lipid metabolism
Online Access:https://doi.org/10.1002/ctm2.810

Internet

https://doi.org/10.1002/ctm2.810

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