Lithium monotherapy increases ACTH and cortisol response in the DEX/CRH test in unipolar depressed subjects. A study with 30 treatment-naive patients.

Lithium monotherapy increases ACTH and cortisol response in the DEX/CRH test in unipolar depressed subjects. A study with 30 treatment-naive patients.

BACKGROUND: Distorted activity of the hypothalamic-pituitary-adrenocortical (HPA) system is one of the most robustly documented biological abnormalities in major depression. Lithium is central to the treatment of affective disorders, but little is known about its effects on the HPA system of depress...

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Bibliographic Details
Main Authors: Tom Bschor, Dirk Ritter, Patricia Winkelmann, Sebastian Erbe, Manfred Uhr, Marcus Ising, Ute Lewitzka
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3223180?pdf=render

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http://europepmc.org/articles/PMC3223180?pdf=render

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