Evaluation of the 50% Infectious Dose of Human Norovirus Cin-2 in Gnotobiotic Pigs: A Comparison of Classical and Contemporary Methods for Endpoint Estimation

Evaluation of the 50% Infectious Dose of Human Norovirus Cin-2 in Gnotobiotic Pigs: A Comparison of Classical and Contemporary Methods for Endpoint Estimation

Human noroviruses (HuNoVs) are the leading causative agents of epidemic and sporadic acute gastroenteritis that affect people of all ages worldwide. However, very few dose–response studies have been carried out to determine the median infectious dose of HuNoVs. In this study, we evaluated the median...

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Bibliographic Details
Main Authors: Ashwin K. Ramesh, Viviana Parreño, Philip J. Schmidt, Shaohua Lei, Weiming Zhong, Xi Jiang, Monica B. Emelko, Lijuan Yuan
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Viruses
Subjects:
median infectious dose
Reed–Muench
Spearman–Karber
approximate beta-Poisson
dose–response
Online Access:https://www.mdpi.com/1999-4915/12/9/955

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https://www.mdpi.com/1999-4915/12/9/955

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