Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

Sclerostin is a protein secreted by osteocytes that is encoded by the SOST gene; it decreases bone formation by reducing osteoblast differentiation through inhibition of the Wnt signaling pathway. Silencing the SOST gene using RNA interference (RNAi) could therefore be an effective way to treat oste...

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Bibliographic Details
Main Authors: Genc Basha, Mina Ordobadi, Wilder R Scott, Andrew Cottle, Yan Liu, Haitang Wang, Pieter R Cullis
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
bone formation
lipid nanoparticles
sclerostin
siRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253117300872

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http://www.sciencedirect.com/science/article/pii/S2162253117300872

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