AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells

AKT inhibition interferes with the expression of immune checkpoint proteins and increases NK-induced killing of HL60-AML cells

ABSTRACT Objective To determine the role of the AKT pathway in the regulating of natural Killer-induced apoptosis of acute myeloid leukemia cells and to characterize the associated molecular mechanisms. Methods BALB/c nude mice were injected with HL60 cells to induce a xenogenic model of subcutane...

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Bibliographic Details
Main Authors: Sofia Mônaco Gama, Vanessa Araújo Varela, Natalia Mazini Ribeiro, Bruna Bizzarro, Camila Hernandes, Thiago Pinheiro Arrais Aloia, Mariane Tami Amano, Welbert Oliveira Pereira
Format: Article
Language:English
Published: Instituto Israelita de Ensino e Pesquisa Albert Einstein 2023-06-01
Series:Einstein (São Paulo)
Subjects:
Leukemia, myeloid, acute
AKT
PD-L1
Gal-9
Killer cells, natural
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100216&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082023000100216&tlng=en

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