H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX

H2A O-GlcNAcylation at serine 40 functions genomic protection in association with acetylated H2AZ or γH2AX

Abstract Background We have previously reported a novel O-GlcNAc modification at serine 40 (S40) of H2A (H2AS40Gc). S40-type H2A isoforms susceptible to O-GlcNAcylation are evolutionarily new and restricted to the viviparous animals; however, the biological function of H2AS40Gc is largely unknown. H...

Full description

Bibliographic Details
Main Authors: Koji Hayakawa, Mitsuko Hirosawa, Ruiko Tani, Chikako Yoneda, Satoshi Tanaka, Kunio Shiota
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Epigenetics & Chromatin
Subjects:
O-GlcNAcylation
Histone modification
Canonical histone
Histone variant
DNA damage
DNA repair
Online Access:http://link.springer.com/article/10.1186/s13072-017-0157-x

Internet

http://link.springer.com/article/10.1186/s13072-017-0157-x

Similar Items