Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice

Lipidome modulation by dietary omega-3 polyunsaturated fatty acid supplementation or selective soluble epoxide hydrolase inhibition suppresses rough LPS-accelerated glomerulonephritis in lupus-prone mice

IntroductionLipopolysaccharide (LPS)-accelerated autoimmune glomerulonephritis (GN) in NZBWF1 mice is a preclinical model potentially applicable for investigating lipidome-modulating interventions against lupus. LPS can be expressed as one of two chemotypes: smooth LPS (S-LPS) or rough LPS (R-LPS) w...

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Bibliographic Details
Main Authors: Olivia K. Favor, Preeti S. Chauhan, Elham Pourmand, Angel M. Edwards, James G. Wagner, Ryan P. Lewandowski, Lauren K. Heine, Jack R. Harkema, Kin Sing Stephen Lee, James J. Pestka
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
lupus
NZBWF1 mouse
soluble epoxide hydrolase
docosahexaenoic acid
glomerulonephritis
rough LPS
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124910/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1124910/full

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