Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis

Potential Genetic Overlap Between Insomnia and Sleep Symptoms in Major Depressive Disorder: A Polygenic Risk Score Analysis

Background: The prevalence of insomnia and hypersomnia in depressed individuals is substantially higher than that found in the general population. Unfortunately, these concurrent sleep problems can have profound effects on the disease course. Although the full biology of sleep remains to be elucidat...

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Main Authors: Lindsay M. Melhuish Beaupre, Arun K. Tiwari, Vanessa F. Gonçalves, Clement C. Zai, Victoria S. Marshe, Cathryn M. Lewis, Nicholas G. Martin, Andrew M. McIntosh, Mark J. Adams, Bernhard T. Baune, Doug F. Levinson, Dorret I. Boomsma, Brenda W. J. H. Penninx, Gerome Breen, Steve Hamilton, Swapnil Awasthi, Stephan Ripke, Lisa Jones, Ian Jones, Enda M. Byrne, Ian B. Hickie, James P. Potash, Jianxin Shi, Myrna M. Weissman, Yuri Milaneschi, Stanley I. Shyn, Eco J. C. de Geus, Gonneke Willemsen, Gregory M. Brown, James L. Kennedy, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Psychiatry
Subjects:
sleep
major depressive disorder
insomnia
hypersomnia
polygenic risk
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.734077/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.734077/full

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