Reduced TREM2 activation in microglia of patients with Alzheimer's disease

Reduced TREM2 activation in microglia of patients with Alzheimer's disease

Loss‐of‐function variants of triggering receptor expressed on myeloid cells 2 (TREM2) increase the risk of developing Alzheimer's disease (AD). The mechanism through which TREM2 contributes to the disease (TREM2 activation vs inactivation) is largely unknown. Here, we analyzed changes in a gene...

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Bibliographic Details
Main Authors: Yuumi Okuzono, Hiroyuki Sakuma, Shuuichi Miyakawa, Masataka Ifuku, Jonghun Lee, Debashree Das, Antara Banerjee, Yang Zhao, Koji Yamamoto, Tatsuya Ando, Shuji Sato
Format: Article
Language:English
Published: Wiley 2021-11-01
Series:FEBS Open Bio
Subjects:
Alzheimer's disease
differential expression analysis
gene set enrichment analysis
microglia
single‐nucleus RNA sequencing
TREM2
Online Access:https://doi.org/10.1002/2211-5463.13300

Internet

https://doi.org/10.1002/2211-5463.13300

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