Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression

Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression

ABSTRACT Apobec3A is involved in the antiviral host defense, targeting nuclear DNA, introducing point mutations, and thereby activating DNA damage response (DDR). Here, we found a significant upregulation of Apobec3A during HAdV infection, including Apobec3A protein stabilization mediated by the vir...

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Bibliographic Details
Main Authors: Lilian Göttig, Christina Weiß, Miona Stubbe, Lisa Hanrieder, Samuel Hofmann, Alessandro Grodziecki, Daniela Stadler, Arnaud Carpentier, Ulrike Protzer, Sabrina Schreiner
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:mBio
Subjects:
HAdV
adenovirus
A3A
Apobec
SUMO
deamination
Online Access:https://journals.asm.org/doi/10.1128/mbio.03478-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03478-22

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