Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice

Kupffer cells prevent pancreatic ductal adenocarcinoma metastasis to the liver in mice

Abstract Although macrophages contribute to cancer cell dissemination, immune evasion, and metastatic outgrowth, they have also been reported to coordinate tumor-specific immune responses. We therefore hypothesized that macrophage polarization could be modulated therapeutically to prevent metastasis...

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Bibliographic Details
Main Authors: Stacy K. Thomas, Max M. Wattenberg, Shaanti Choi-Bose, Mark Uhlik, Ben Harrison, Heather Coho, Christopher R. Cassella, Meredith L. Stone, Dhruv Patel, Kelly Markowitz, Devora Delman, Michael Chisamore, Jeremy Drees, Nandita Bose, Gregory L. Beatty
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41771-z

Internet

https://doi.org/10.1038/s41467-023-41771-z

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