Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis

Albumin-induced premature senescence in human renal proximal tubular cells and its relationship with intercellular fibrosis

The presence of senescent cells is associated with renal fibrosis. This study aims to investigate the effect of albumin-induced premature senescence on tubulointerstitial fibrosis and its possible mechanism in vitro. Different concentrations of bovine serum albumim (BSA) with or without si-p21 are u...

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Bibliographic Details
Main Authors: Lu Wen, Ren Shijing, Dong Wenhui, Li Xiaomin, Zheng Zongji, Jia Yijie, Xue Yaoming
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2022-06-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
senescence
human renal proximal tubular cell
fibrosis, G2/M arrest
p21
albuminuria
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2022055

Internet

https://www.sciengine.com/doi/10.3724/abbs.2022055

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