Distinguishing between exploratory and confirmatory preclinical research will improve translation.

Preclinical researchers confront two overarching agendas related to drug development: selecting interventions amid a vast field of candidates, and producing rigorous evidence of clinical promise for a small number of interventions. We suggest that each challenge is best met by two different, complem...

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Bibliographic Details
Main Authors: Jonathan Kimmelman, Jeffrey S Mogil, Ulrich Dirnagl
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-05-01
Series:PLoS Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24844265/?tool=EBI