Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Digitoxin Inhibits Epithelial-to-Mesenchymal-Transition in Hereditary Castration Resistant Prostate Cancer

Castration Resistant Prostate Cancer (CRPC) is thought to be driven by a collaborative mechanism between TNFα/NFκB and TGFβ signaling, leading to inflammation, Epithelial-to-Mesenchymal-Transition (EMT), and metastasis. Initially, TGFβ is a tumor suppressor, but in advanced metastatic disease it swi...

Full description

Bibliographic Details
Main Authors: Bette S. Pollard, Mark. A. Suckow, William R. Wolter, Joshua M. Starr, Ofer Eidelman, Clifton L. Dalgard, Parameet Kumar, Sharmistha Battacharyya, Meera Srivastava, Roopa Biswas, Matthew D. Wilkerson, Xijun Zhang, Qingfeng Yang, Harvey B. Pollard
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Oncology
Subjects:
prostate cancer
hereditary
digitoxin
TGFβ
NFκB
TGFBR2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00630/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.00630/full

Similar Items