KDM7A-DT induces genotoxic stress, tumorigenesis, and progression of p53 missense mutation-associated invasive breast cancer

KDM7A-DT induces genotoxic stress, tumorigenesis, and progression of p53 missense mutation-associated invasive breast cancer

Stress-induced promoter-associated and antisense lncRNAs (si-paancRNAs) originate from a reservoir of oxidative stress (OS)-specific promoters via RNAPII pausing-mediated divergent antisense transcription. Several studies have shown that the KDM7A divergent transcript gene (KDM7A-DT), which encodes...

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Bibliographic Details
Main Authors: Antonis Giannakakis, Margaritis Tsifintaris, Vasileios Gouzouasis, Ghim Siong Ow, Mei Yee Aau, Csaba Papp, Anna V. Ivshina, Vladimir A. Kuznetsov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-05-01
Series:Frontiers in Oncology
Subjects:
KDM7A-DT
oxidative stress
breast cancer
genotoxic stress
TP53 mutation
DNA damage response and repair
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2024.1227151/full

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https://www.frontiersin.org/articles/10.3389/fonc.2024.1227151/full

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