FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis

FOXO3 Expression in Macrophages Is Lowered by a High-Fat Diet and Regulates Colonic Inflammation and Tumorigenesis

Obesity, characterized by augmented inflammation and tumorigenesis, is linked to genetic predispositions, such as FOXO3 polymorphisms. As obesity is associated with aberrant macrophages infiltrating different tissues, including the colon, we aimed to identify FOXO3-dependent transcriptomic changes i...

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Bibliographic Details
Main Authors: Rida Iftikhar, Harrison M. Penrose, Angelle N. King, Yunah Kim, Emmanuelle Ruiz, Emad Kandil, Heather L. Machado, Suzana D. Savkovic
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Metabolites
Subjects:
macrophages
FOXO3
obesity
inflammation
tumorigenesis
IBD
Online Access:https://www.mdpi.com/2218-1989/12/3/250

Internet

https://www.mdpi.com/2218-1989/12/3/250

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