Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon

Differential Host Pro-Inflammatory Response to Mycobacterial Cell Wall Lipids Regulated by the Mce1 Operon

The cell wall of wild-type (WT) Mycobacterium tuberculosis (Mtb), an etiologic agent of tuberculosis (TB) and a Mtb strain disrupted in a 13-gene operon mce1 (Δmce1) varies by more than 400 lipid species. Here, we examined Mtb lipid-induced response in murine macrophage, as well as in human T-cell s...

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Bibliographic Details
Main Authors: Jéssica D. Petrilli, Igor Müller, Luana E. Araújo, Thiago M. Cardoso, Lucas P. Carvalho, Bruna C. Barros, Maurício Teixeira, Sérgio Arruda, Lee W. Riley, Adriano Queiroz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Immunology
Subjects:
Mycobacterium tuberculosis
lipid-induced responses
mce1 operon
mycobacterial cell wall lipid
inflammation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01848/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01848/full

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