CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy

CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy

The benefits of CAR-T therapy could be expanded to the treatment of solid tumors through the use of derived autologous αβ T cell, but clinical trials of CAR-T therapy for patients with solid tumors have so far been disappointing. CAR-T therapy also faces hurdles due to the time and cost intensive pr...

Full description

Bibliographic Details
Main Authors: Yizheng Wang, Linan Wang, Naohiro Seo, Satoshi Okumura, Tae Hayashi, Yasushi Akahori, Hiroshi Fujiwara, Yasunori Amaishi, Sachiko Okamoto, Junichi Mineno, Yoshimasa Tanaka, Takuma Kato, Hiroshi Shiku
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
Vγ9Vδ2 T cell
chimeric antigen receptor (CAR)
carcinoembryonic antigen (CEA)
graft-versus-host disease (GVHD)
off-the-shelf
glucocorticoid-induced TNFR-related protein (GITR)
Online Access:https://www.mdpi.com/1422-0067/24/13/10873

Internet

https://www.mdpi.com/1422-0067/24/13/10873

Similar Items