Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis

Archaeal GPN-loop GTPases involve a lock-switch-rock mechanism for GTP hydrolysis

ABSTRACTThree GPN-loop GTPases, GPN1–GPN3, are central to the maturation and trafficking of eukaryotic RNA polymerase II. This GTPase family is widely represented in archaea but typically occurs as single paralogs. Structural analysis of the GTP- and GDP-bound states of the Sulfolobus acidocaldarius...

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Bibliographic Details
Main Authors: Lukas Korf, Xing Ye, Marian S. Vogt, Wieland Steinchen, Mohamed Watad, Chris van der Does, Maxime Tourte, Shamphavi Sivabalasarma, Sonja-Verena Albers, Lars-Oliver Essen
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:mBio
Subjects:
GPN-loop
GTPase
sulfolobus
RNA polymerase II
allostery
Online Access:https://journals.asm.org/doi/10.1128/mbio.00859-23

Internet

https://journals.asm.org/doi/10.1128/mbio.00859-23

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