Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying the isoprenoid-feeding module and blocking the menaquinone pathway in Escherichia coli

Improving squalene production by enhancing the NADPH/NADP+ ratio, modifying the isoprenoid-feeding module and blocking the menaquinone pathway in Escherichia coli

Abstract Background Squalene is currently used widely in the food, cosmetics, and medicine industries. It could also replace petroleum as a raw material for fuels. Microbial fermentation processes for squalene production have been emerging over recent years. In this study, to study the squalene-prod...

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Bibliographic Details
Main Authors: Wen Xu, Jia Yao, Lijun Liu, Xi Ma, Wei Li, Xiaojing Sun, Yang Wang
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Biotechnology for Biofuels
Subjects:
Squalene
UdhA
pgi
Feeding module modification
Rate-limiting enzymes
Menaquinone pathway
Online Access:http://link.springer.com/article/10.1186/s13068-019-1415-x

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http://link.springer.com/article/10.1186/s13068-019-1415-x

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