Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions

Intrinsic Disorder in Proteins with Pathogenic Repeat Expansions

Intrinsically disordered proteins and proteins with intrinsically disordered regions have been shown to be highly prevalent in disease. Furthermore, disease-causing expansions of the regions containing tandem amino acid repeats often push repetitive proteins towards formation of irreversible aggrega...

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Bibliographic Details
Main Authors: April L. Darling, Vladimir N. Uversky
Format: Article
Language:English
Published: MDPI AG 2017-11-01
Series:Molecules
Subjects:
protein repeat expansion
intrinsically disordered protein
intrinsically disordered protein region
homorepeats
protein aggregation
proteinopathies
Online Access:https://www.mdpi.com/1420-3049/22/12/2027

Internet

https://www.mdpi.com/1420-3049/22/12/2027

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