Auraptene Enhances Junction Assembly in Cerebrovascular Endothelial Cells by Promoting Resilience to Mitochondrial Stress through Activation of Antioxidant Enzymes and mtUPR

Auraptene Enhances Junction Assembly in Cerebrovascular Endothelial Cells by Promoting Resilience to Mitochondrial Stress through Activation of Antioxidant Enzymes and mtUPR

Junctional proteins in cerebrovascular endothelial cells are essential for maintaining the barrier function of the blood-brain barrier (BBB), thus protecting the brain from the infiltration of pathogens. The present study showed that the potential therapeutic natural compound auraptene (AUR) enhance...

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Bibliographic Details
Main Authors: Min Joung Lee, Yunseon Jang, Jiebo Zhu, Eunji Namgung, Dahyun Go, Changjun Seo, Xianshu Ju, Jianchen Cui, Yu Lim Lee, Hyoeun Kang, Hyeongseok Kim, Woosuk Chung, Jun Young Heo
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
auraptene
endothelial cell
blood-brain barrier
antioxidant
mitochondria
mtUPR
Online Access:https://www.mdpi.com/2076-3921/10/3/475

Internet

https://www.mdpi.com/2076-3921/10/3/475

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