Together is Better: mRNA Co‐Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co‐Delivery and Protein Expression on the Single Cell Level

Together is Better: mRNA Co‐Encapsulation in Lipoplexes is Required to Obtain Ratiometric Co‐Delivery and Protein Expression on the Single Cell Level

Abstract Liposomes can efficiently deliver messenger RNA (mRNA) into cells. When mRNA cocktails encoding different proteins are needed, a considerable challenge is to efficiently deliver all mRNAs into the cytosol of each individual cell. In this work, two methods are explored to co‐deliver varying...

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Bibliographic Details
Main Authors: Heyang Zhang, Jeroen Bussmann, Florian H. Huhnke, Joke Devoldere, An‐Katrien Minnaert, Wim Jiskoot, Friedhelm Serwane, Joachim Spatz, Magnus Röding, Stefaan C. De Smedt, Kevin Braeckmans, Katrien Remaut
Format: Article
Language:English
Published: Wiley 2022-02-01
Series:Advanced Science
Subjects:
cellular uptake
mingle/single‐mRNA lipoplex
protein expression
single cell
theoretical modeling
Online Access:https://doi.org/10.1002/advs.202102072

Internet

https://doi.org/10.1002/advs.202102072

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