Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus via the STING Pathway

Cell-Free DNA Promotes Inflammation in Patients With Oral Lichen Planus via the STING Pathway

BackgroundDamaged and dead cells release cell-free DNA (cfDNA) that activates cyclic GMP–AMP (cGAMP) synthase (cGAS), which leads to the activation of stimulator of interferon genes (STING) via the second messenger cGAMP. STING promotes the production of inflammatory cytokines and type I interferons...

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Bibliographic Details
Main Authors: Jing Deng, Weiyi Pan, Ning Ji, Na Liu, Qian Chen, Jinhuan Chen, Yutong Sun, Liang Xie, Qianming Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
oral lichen planus
inflammation
cfDNA
THP-1 macrophages
PAMAM-G3
STING
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.838109/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.838109/full

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