FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration

FURIN Expression in Vascular Endothelial Cells Is Modulated by a Coronary Artery Disease–Associated Genetic Variant and Influences Monocyte Transendothelial Migration

Background Genome‐wide association studies have shown an association between the single‐nucleotide polymorphism rs17514846 on chromosome 15q26.1 and coronary artery disease susceptibility. The underlying biological mechanism is, however, not fully understood. rs17514846 is located in the FES Upstrea...

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Bibliographic Details
Main Authors: Xu Yang, Wei Yang, David G. McVey, Guojun Zhao, Jinfu Hu, Robin N. Poston, Meixia Ren, Karin Willeit, Stefan Coassin, Johann Willeit, Thomas R. Webb, Nilesh J. Samani, Manuel Mayr, Stefan Kiechl, Shu Ye
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
coronary artery disease
endothelial cells
FURIN
single‐nucleotide polymorphism
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.014333

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.119.014333

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