Joint metabolomics and transcriptomics analysis systematically reveal the impact of MYCN in neuroblastoma

Joint metabolomics and transcriptomics analysis systematically reveal the impact of MYCN in neuroblastoma

Abstract The limited understanding of the molecular mechanism underlying MYCN-amplified (MNA) neuroblastoma (NB) has hindered the identification of effective therapeutic targets for MNA NB, contributing to its higher mortality rate compared to MYCN non-amplified (non-MNA) NB. Therefore, a comprehens...

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Bibliographic Details
Main Authors: Bang Du, Yingyu Zhang, Pin Zhang, Mengxin Zhang, Zhidan Yu, Lifeng Li, Ligong Hou, Qionglin Wang, Xianwei Zhang, Wancun Zhang
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
MYCN amplification
Neuroblastoma
Metabolomics
Transcriptomics
Therapeutic target
Molecular mechanism
Online Access:https://doi.org/10.1038/s41598-024-71211-x

Internet

https://doi.org/10.1038/s41598-024-71211-x

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