Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice

Intravital Microscopic Evaluation of the Effects of a CXCR2 Antagonist in a Model of Liver Ischemia Reperfusion Injury in Mice

BackgroundIschemia–reperfusion (IR) is a major contributor to graft rejection after liver transplantation. During IR injury, an intense inflammatory process occurs in the liver. Neutrophils are considered central players in the events that lead to liver injury. CXC chemokines mediate hepatic inflamm...

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Bibliographic Details
Main Authors: Thiago Henrique Caldeira de Oliveira, Pedro Elias Marques, Fariba Poosti, Pieter Ruytinx, Flávio Almeida Amaral, Laura Brandolini, Marcello Allegretti, Paul Proost, Mauro Martins Teixeira
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
hepatic ischemia–reperfusion
chemokines
CXCR2
neutrophil-mediated liver injury
neutrophil migration
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01917/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01917/full

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