A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor

A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor

Summary: In the search for much-needed new antibacterial chemical matter, a myriad of compounds have been reported in academic and pharmaceutical screening endeavors. Only a small fraction of these, however, are characterized with respect to mechanism of action (MOA). Here, we describe a pipeline th...

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Những tác giả chính: Shawn French, Amelia Bing Ya Guo, Michael J. Ellis, Julia P. Deisinger, Jarrod W. Johnson, Kenneth Rachwalski, Zoë A. Piquette, Telmah Lluka, Miranda Zary, Sineli Gamage, Jakob Magolan, Eric D. Brown
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Elsevier 2024-04-01
Loạt:Cell Reports
Những chủ đề:
CP: Microbiology
Truy cập trực tuyến:http://www.sciencedirect.com/science/article/pii/S2211124724003814

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http://www.sciencedirect.com/science/article/pii/S2211124724003814

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