A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor
Summary: In the search for much-needed new antibacterial chemical matter, a myriad of compounds have been reported in academic and pharmaceutical screening endeavors. Only a small fraction of these, however, are characterized with respect to mechanism of action (MOA). Here, we describe a pipeline th...
Main Authors: | Shawn French, Amelia Bing Ya Guo, Michael J. Ellis, Julia P. Deisinger, Jarrod W. Johnson, Kenneth Rachwalski, Zoë A. Piquette, Telmah Lluka, Miranda Zary, Sineli Gamage, Jakob Magolan, Eric D. Brown |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2024-04-01
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Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724003814 |
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