Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice

Melanocortin receptor agonist NDP-α-MSH improves cognitive deficits and microgliosis but not amyloidosis in advanced stages of AD progression in 5XFAD and 3xTg mice

IntroductionAlzheimer’s disease (AD) is the most frequent cause of dementia and still lacks effective therapy. Clinical signs of AD include low levels of endogenous melanocortins (MCs) and previous studies have shown that treatment with MC analogs induces neuroprotection in the early stages of AD. M...

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Bibliographic Details
Main Authors: Eleonora Daini, Eleonora Vandini, Martina Bodria, Wenjie Liao, Carlo Baraldi, Valentina Secco, Alessandra Ottani, Michele Zoli, Daniela Giuliani, Antonietta Vilella
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Immunology
Subjects:
5XFAD
3xTg
cognitive deficits
neuroprotection
NDP-α-MSH
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082036/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082036/full

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