ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis

ELOVL4 Mutations That Cause Spinocerebellar Ataxia-34 Differentially Alter Very Long Chain Fatty Acid Biosynthesis

The FA Elongase-4 (ELOVL4) enzyme mediates biosynthesis of both very long chain (VLC)-PUFAs and VLC-saturated FA (VLC-SFAs). VLC-PUFAs play critical roles in retina and sperm function, whereas VLC-SFAs are predominantly associated with brain function and maintenance of the skin permeability barrier....

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Bibliographic Details
Main Authors: Yeboah Kofi Gyening, Neeraj Kumar Chauhan, Madison Tytanic, Vicki Ea, Richard S. Brush, Martin-Paul Agbaga
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Lipid Research
Subjects:
lipids
elongation of very long chain fatty acid-4
eye/retina
saturated fatty acid
fatty acid metabolism
omega-3 fatty acids
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752200150X

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http://www.sciencedirect.com/science/article/pii/S002222752200150X

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