Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis

Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-β2 axis

Abstract Background Due to the complexity of the mechanisms involved in epileptogenesis, the available antiseizure drugs (ASDs) do not meet clinical needs; hence, both the discovery of new ASDs and the elucidation of novel molecular mechanisms are very important. Methods BALB/c mice were utilized to...

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Bibliographic Details
Main Authors: Yan Hu, Buliang Meng, Saige Yin, Meifeng Yang, Yilin Li, Naixin Liu, Shanshan Li, Yixiang Liu, Dandan Sun, Siyu Wang, Yinglei Wang, Zhe Fu, Yutong Wu, Ailan Pang, Jun Sun, Ying Wang, Xinwang Yang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Neuroinflammation
Subjects:
Epilepsy
Peptide
circ_0001293/miR-8114/TGF-β2
NF-κB signaling pathway
MAPK signaling pathway
Online Access:https://doi.org/10.1186/s12974-022-02647-z

Internet

https://doi.org/10.1186/s12974-022-02647-z

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