Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain

Matrix metalloproteinase 9 regulates cell death following pilocarpine-induced seizures in the developing brain

Matrix metalloproteinases (MMPs) are involved in tissue repair, cell death and morphogenesis. We investigated the role of the gelatinases MMP-2 and MMP-9 in the pathogenesis of neuronal death induced by prolonged seizures in the developing brain.Seven-day-old rats, MMP-9 knockout mice and transgenic...

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Bibliographic Details
Main Authors: Yvonne Hoehna, Ortrud Uckermann, Hella Luksch, Vanya Stefovska, Jenny Marzahn, Marlen Theil, Tomasz Gorkiewicz, Maciej Gawlak, Grzegorz M. Wilczynski, Leszek Kaczmarek, Chrysanthy Ikonomidou
Format: Article
Language:English
Published: Elsevier 2012-12-01
Series:Neurobiology of Disease
Subjects:
Development
Seizure
Cell death
Gelatinase
MMP
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996112002380

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http://www.sciencedirect.com/science/article/pii/S0969996112002380

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