Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target

Network toxicology and molecular docking analyses on strychnine indicate CHRM1 is a potential neurotoxic target

Abstract Background Improper use of strychnine can cause death. The aim of this study was to identify and evaluate toxic mechanisms of action associated with active compounds in strychnine using a network toxicology approach, and explore potential pathogenic targets. Methods In the present study, st...

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Bibliographic Details
Main Authors: Jialin Dai, Jiangjin Liu, Maoxin Zhang, Yanni Yu, Jie Wang
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Network toxicology
Molecular docking
Strychnine
CHRM1
Online Access:https://doi.org/10.1186/s12906-022-03753-4

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