Measles virus epitope presentation by HLA: novel insights into epitope selection, dominance and microvariation

Measles virus epitope presentation by HLA: novel insights into epitope selection, dominance and microvariation

Immunity to infections with Measles Virus (MV) can involve vigorous HLA class I restricted CD8+ cytotoxic T cell (CTL) responses. MV, albeit regarded monotypic, is known to undergo molecular evolution across its RNA genome. To address which regions of the MV proteome are eligible for recognition by...

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Bibliographic Details
Main Authors: Ingrid eSchellens, Hugo D Meiring, Ilka eHoof, Sanne eSpijkers, Martien C.M. Poelen, Jacqueline A.M. van Gaans-van den Brink, Ana I Costa, Harry eVennema, Can eKesmir, Debbie eVan Baarle, Cecile A.C.M. Van Els
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Immunology
Subjects:
Epitope Mapping
HLA-A Antigens
HLA-B Antigens
HLA-C Antigens
Measles virus
immunodominance
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00546/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00546/full

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