A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation
A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoumarin 6 employing an appropriate solvent of CS2–PhNO2...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2016-11-01
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Series: | Arabian Journal of Chemistry |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535212000950 |