A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation

A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel–Crafts tigloylation of 5,7-dihydroxy-4-n-propyl thiocoumarin 6 employing an appropriate solvent of CS2–PhNO2...

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Bibliographic Details
Main Authors: Anil U. Chopade, Manojkumar U. Chopade, Bhanu M. Chanda, Dilip D. Sawaikar, Kiran B. Sonawane, Mukund K. Gurjar
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535212000950