Identification of feature genes and key biological pathways in immune-mediated necrotizing myopathy: High-throughput sequencing and bioinformatics analysis

Identification of feature genes and key biological pathways in immune-mediated necrotizing myopathy: High-throughput sequencing and bioinformatics analysis

Background: Immune-mediated necrotizing myopathy (IMNM), a subgroup of idiopathic inflammatory myopathies (IIMs), is characterized by severe proximal muscle weakness and prominent necrotic fibers but no infiltration of inflammatory cells. IMNM pathogenesis is unclear. This study investigated key bio...

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Bibliographic Details
Main Authors: Kai Chen, Chun-yan Zhu, Jia-ying Bai, Feng Xiao, Song Tan, Qiao Zhou, Li Zeng
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
IMNM
RNA sequencing
Biomarkers
Immune cell infiltration
Autophay-lysosome pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037023001186

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http://www.sciencedirect.com/science/article/pii/S2001037023001186

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