Ceftriaxone exerts antitumor effects in MYCN‐driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression

Ceftriaxone exerts antitumor effects in MYCN‐driven retinoblastoma and neuroblastoma by targeting DDX3X for translation repression

MYCN proto‐oncogene, bHLH transcription factor (MYCN) amplification is associated with aggressive retinoblastoma (RB) and neuroblastoma (NB) cancer recurrence that is resistant to chemotherapies. Therefore, there is an urgent need to identify new therapeutic tools. This study aimed to evaluate the p...

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Bibliographic Details
Main Authors: Pamorn Chittavanich, Duangporn Saengwimol, Sittiruk Roytrakul, Duangnate Rojanaporn, Vijender Chaitankar, Atthapol Srimongkol, Usanarat Anurathapan, Suradej Hongeng, Rossukon Kaewkhaw
Format: Article
Language:English
Published: Wiley 2024-04-01
Series:Molecular Oncology
Subjects:
ceftriaxone
DDX3X
MYCN amplification
neuroblastoma
retinoblastoma
translation
Online Access:https://doi.org/10.1002/1878-0261.13553

Internet

https://doi.org/10.1002/1878-0261.13553

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