Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies

Plasma cell-free RNA profiling distinguishes cancers from pre-malignant conditions in solid and hematologic malignancies

Abstract Cell-free RNA (cfRNA) in plasma reflects phenotypic alterations of both localized sites of cancer and the systemic host response. Here we report that cfRNA sequencing enables the discovery of messenger RNA (mRNA) biomarkers in plasma with the tissue of origin-specific to cancer types and pr...

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Bibliographic Details
Main Authors: Breeshey Roskams-Hieter, Hyun Ji Kim, Pavana Anur, Josiah T. Wagner, Rowan Callahan, Elias Spiliotopoulos, Charles Ward Kirschbaum, Fehmi Civitci, Paul T. Spellman, Reid F. Thompson, Khashayar Farsad, Willscott E. Naugler, Thuy T. M. Ngo
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-022-00270-y

Internet

https://doi.org/10.1038/s41698-022-00270-y

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