Convection Enhanced Delivery in the Setting of High-Grade Gliomas
Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-04-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/13/4/561 |
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| author | Chibueze D. Nwagwu Amanda V. Immidisetti Michael Y. Jiang Oluwasegun Adeagbo David C. Adamson Anne-Marie Carbonell |
| author_facet | Chibueze D. Nwagwu Amanda V. Immidisetti Michael Y. Jiang Oluwasegun Adeagbo David C. Adamson Anne-Marie Carbonell |
| author_sort | Chibueze D. Nwagwu |
| collection | DOAJ |
| description | Development of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas. |
| first_indexed | 2024-03-10T12:17:26Z |
| format | Article |
| id | doaj.art-8390e4ba2b9a4d398b7ff5386a53ec89 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-10T12:17:26Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-8390e4ba2b9a4d398b7ff5386a53ec892023-11-21T15:46:22ZengMDPI AGPharmaceutics1999-49232021-04-0113456110.3390/pharmaceutics13040561Convection Enhanced Delivery in the Setting of High-Grade GliomasChibueze D. Nwagwu0Amanda V. Immidisetti1Michael Y. Jiang2Oluwasegun Adeagbo3David C. Adamson4Anne-Marie Carbonell5Emory University School of Medicine, Atlanta, GA 30322, USARobert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USAImperial College School of Medicine, London SW7 2DD, UKEmory University School of Medicine, Atlanta, GA 30322, USADepartment of Neurosurgery, School of Medicine, Emory University, Atlanta, GA 30322, USAOncoSynergy, Inc., Stamford, CT 06902, USADevelopment of effective treatments for high-grade glioma (HGG) is hampered by (1) the blood–brain barrier (BBB), (2) an infiltrative growth pattern, (3) rapid development of therapeutic resistance, and, in many cases, (4) dose-limiting toxicity due to systemic exposure. Convection-enhanced delivery (CED) has the potential to significantly limit systemic toxicity and increase therapeutic index by directly delivering homogenous drug concentrations to the site of disease. In this review, we present clinical experiences and preclinical developments of CED in the setting of high-grade gliomas.https://www.mdpi.com/1999-4923/13/4/561glioblastomahigh-grade gliomarefractory gliomadirect deliveryconvection enhanced deliveryneuro-oncology |
| spellingShingle | Chibueze D. Nwagwu Amanda V. Immidisetti Michael Y. Jiang Oluwasegun Adeagbo David C. Adamson Anne-Marie Carbonell Convection Enhanced Delivery in the Setting of High-Grade Gliomas Pharmaceutics glioblastoma high-grade glioma refractory glioma direct delivery convection enhanced delivery neuro-oncology |
| title | Convection Enhanced Delivery in the Setting of High-Grade Gliomas |
| title_full | Convection Enhanced Delivery in the Setting of High-Grade Gliomas |
| title_fullStr | Convection Enhanced Delivery in the Setting of High-Grade Gliomas |
| title_full_unstemmed | Convection Enhanced Delivery in the Setting of High-Grade Gliomas |
| title_short | Convection Enhanced Delivery in the Setting of High-Grade Gliomas |
| title_sort | convection enhanced delivery in the setting of high grade gliomas |
| topic | glioblastoma high-grade glioma refractory glioma direct delivery convection enhanced delivery neuro-oncology |
| url | https://www.mdpi.com/1999-4923/13/4/561 |
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