Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

Membrane Heteroreceptor Complexes as Second-Order Protein Modulators: A Novel Integrative Mechanism through Allosteric Receptor–Receptor Interactions

Bioluminescence and fluorescence resonance energy transfer (BRET and FRET) together with the proximity ligation method revealed the existence of G-protein-coupled receptors, Ionotropic and Receptor tyrosine kinase heterocomplexes, e.g., A2AR–D2R, GABAA–D5R, and FGFR1–5-HT1AR heterocomplexes. Molecul...

Full description

Bibliographic Details
Main Authors: Marina Mirchandani-Duque, Malak Choucri, Juan C. Hernández-Mondragón, Minerva Crespo-Ramírez, Catalina Pérez-Olives, Luca Ferraro, Rafael Franco, Miguel Pérez de la Mora, Kjell Fuxe, Dasiel O. Borroto-Escuela
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Membranes
Subjects:
G-protein-coupled receptors
oligomerization
heteroreceptor complexes
protein modulation
meta modulation
Online Access:https://www.mdpi.com/2077-0375/14/5/96

Internet

https://www.mdpi.com/2077-0375/14/5/96

Similar Items