The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling...

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Bibliographic Details
Main Authors: Michael Yu, Kevin Qin, Jiaming Fan, Guozhi Zhao, Piao Zhao, Wei Zeng, Connie Chen, Annie Wang, Yonghui Wang, Jiamin Zhong, Yi Zhu, William Wagstaff, Rex C. Haydon, Hue H. Luu, Sherwin Ho, Michael J. Lee, Jason Strelzow, Russell R. Reid, Tong-Chuan He
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2024-05-01
Series:Genes and Diseases
Subjects:
β-Catenin
Cancer
Canonical Wnt
Disease
Non-canonical Wnt
Stem cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2352304223002945

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http://www.sciencedirect.com/science/article/pii/S2352304223002945

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