SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells

SIRT3 inhibition suppresses hypoxia‐inducible factor 1α signaling and alleviates hypoxia‐induced apoptosis of type B spermatogonia GC‐2 cells

Hypoxia has been reported to be an important factor leading to male infertility, and it has been reported that hypoxia can induce the apoptosis of mouse spermatogenic cells. Sirtuin 3 (SIRT3) has been reported to promote the degradation of hypoxia‐inducible factor 1α (HIF‐1α), and thus, we hypothesi...

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Bibliographic Details
Main Authors: Zixuan Wang, Chunchun Zhu, Yangyang Song, Xiaoyun Chen, Jie Zheng, Lian He, Xing Liu, Zhu Chen
Format: Article
Language:English
Published: Wiley 2023-01-01
Series:FEBS Open Bio
Subjects:
apoptosis
GC‐2
HIF‐1α
hypoxia
SIRT3
spermatogonia
Online Access:https://doi.org/10.1002/2211-5463.13523

Internet

https://doi.org/10.1002/2211-5463.13523

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