Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

Criticality and degeneracy in injury-induced changes in primary afferent excitability and the implications for neuropathic pain

Neuropathic pain remains notoriously difficult to treat despite numerous drug targets. Here, we offer a novel explanation for this intractability. Computer simulations predicted that qualitative changes in primary afferent excitability linked to neuropathic pain arise through a switch in spike initi...

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Bibliographic Details
Main Authors: Stéphanie Ratté, Yi Zhu, Kwan Yeop Lee, Steven A Prescott
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-04-01
Series:eLife
Subjects:
neuropathic pain
degeneracy
excitability
membrane potential oscillation
dynamic clamp
bursting
Online Access:https://elifesciences.org/articles/02370

Internet

https://elifesciences.org/articles/02370

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