Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.

Abnormal interactions between perifollicular mast cells and CD8+ T-cells may contribute to the pathogenesis of alopecia areata.

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are crucial immunomodulatory cells implicated in the regulation of T cell-dependent immunity, IP, and hair growth. Therefo...

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Bibliographic Details
Main Authors: Marta Bertolini, Federica Zilio, Alfredo Rossi, Patrick Kleditzsch, Vladimir E Emelianov, Amos Gilhar, Aviad Keren, Katja C Meyer, Eddy Wang, Wolfgang Funk, Kevin McElwee, Ralf Paus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4022513?pdf=render

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http://europepmc.org/articles/PMC4022513?pdf=render

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