Probing PAC1 receptor activation across species with an engineered sensor

Probing PAC1 receptor activation across species with an engineered sensor

Class-B1 G-protein-coupled receptors (GPCRs) are an important family of clinically relevant drug targets that remain difficult to investigate via high-throughput screening and in animal models. Here, we engineered PAClight1P78A, a novel genetically encoded sensor based on a class-B1 GPCR (the human...

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Bibliographic Details
Main Authors: Reto B Cola, Salome N Niethammer, Preethi Rajamannar, Andrea Gresch, Musadiq A Bhat, Kevin Assoumou, Elyse T Williams, Patrick Hauck, Nina Hartrampf, Dietmar Benke, Miriam Stoeber, Gil Levkowitz, Sarah Melzer, Tommaso Patriarchi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-08-01
Series:eLife
Subjects:
human
PACAP
adenylate cyclase-activating polypeptide
PAC1 receptor
vasoactive intestinal peptide
VIP
Online Access:https://elifesciences.org/articles/96496

Internet

https://elifesciences.org/articles/96496

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