Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice

Periodontal Infection Aggravates C1q-Mediated Microglial Activation and Synapse Pruning in Alzheimer’s Mice

Periodontitis is a dysbiotic infectious disease that leads to the destruction of tooth supporting tissues. There is increasing evidence that periodontitis may affect the development and severity of Alzheimer’s disease (AD). However, the mechanism(s) by which periodontal infection impacts the neurode...

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Bibliographic Details
Main Authors: Xiaoxiao Hao, Zhaofei Li, Wei Li, Jannet Katz, Suzanne M. Michalek, Scott R. Barnum, Lucas Pozzo-Miller, Takashi Saito, Takaomi C. Saido, Qin Wang, Erik D. Roberson, Ping Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
Periodontitis
Porphyromonas gingivalis
Alzheimer’s disease
microglia
complement C1q
synapse loss
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.816640/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.816640/full

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