The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.

The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME.

The human tumour antigen PRAME (preferentially expressed antigen in melanoma) is frequently overexpressed during oncogenesis, and high PRAME levels are associated with poor clinical outcome in a variety of cancers. However, the molecular pathways in which PRAME is implicated are not well understood....

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Bibliographic Details
Main Authors: Adalberto Costessi, Nawel Mahrour, Vikram Sharma, Rieka Stunnenberg, Marieke A Stoel, Esther Tijchon, Joan W Conaway, Ronald C Conaway, Hendrik G Stunnenberg
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3418287?pdf=render

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http://europepmc.org/articles/PMC3418287?pdf=render

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