Gain of function in somatic TP53 mutations is associated with immune‐rich breast tumors and changes in tumor‐associated macrophages

Gain of function in somatic TP53 mutations is associated with immune‐rich breast tumors and changes in tumor‐associated macrophages

Abstract Background Somatic mutations in TP53 are present in 20%–30% of all breast tumors. While there are numerous population‐based analyses of TP53, yet none have examined the relationship between somatic mutations in TP53 and tumor invasive immune cells. Methods Clinical and genetic data from 601...

Full description

Bibliographic Details
Main Authors: Michael Behring, Ana I. Vazquez, Xiangqin Cui, Marguerite R. Irvin, Akinyemi I. Ojesina, Sumit Agarwal, Upender Manne, Sadeep Shrestha
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Molecular Genetics & Genomic Medicine
Subjects:
breast cancer
TP53 gain of function
tumor‐associated macrophages
tumor‐invasive lymphocytes
Online Access:https://doi.org/10.1002/mgg3.1001

Internet

https://doi.org/10.1002/mgg3.1001

Similar Items