PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression

PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression

Tsp-1 in the tumor microenvironment is known to suppress tumor growth and progression. Here the authors show that PRSS2 represses Tsp-1 by binding to lipoprotein receptor-related protein 1 and suggest targeting PRSS2 mediated Tsp-1 repression as a potential therapeutic strategy.

Bibliographic Details
Main Authors: Lufei Sui, Suming Wang, Debolina Ganguly, Tyler P. El Rayes, Cecilie Askeland, Astrid Børretzen, Danielle Sim, Ole Johan Halvorsen, Gøril Knutsvik, Jarle Arnes, Sura Aziz, Svein Haukaas, William D. Foulkes, Diane R. Bielenberg, Arturas Ziemys, Vivek Mittal, Rolf A. Brekken, Lars A. Akslen, Randolph S. Watnick
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35649-9

Internet

https://doi.org/10.1038/s41467-022-35649-9

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